Capacitance immunosensors

J.S. Li, Z.S. Wu, H. Wang, G.L. Shen, and R.Q. Yu, A reusable capacitive immunosensor with a novel immobilization procedure based on 1,6-hexanedithiol and nano-Au self-assembled layers. Sens. Actuators B 110, 327-334 (2005). 

B. Prasad and R. Lai, A capacitative immunosensor measurement system with a lock-in amplifier and potentiostatic control by software. Meas. Sci. Technol. 10,1097—1104 (1999). 

Instrumental electroanalysis offers some alternatives for the detection of biological recognition events in immunosensors such as capacitive immunosensors and sensors based on electrochemical impedance spectroscopy. Both techniques are universal platforms for the detection of immunoreactions and hence bacteria, viruses, tumor markers, and more, as described above, have been detected with these methods. 

Betty CA (2009) Highly sensitive capacitive immunosensor based on porous silicon-polyaniline sfructure bias dependence on specificity. Biosens Bioelectron 25 338... 

Li, D., Feng, Y., Zhou, L. et al. (2011) Label-free capacitive immunosensor based on quartz crystal Au electfode for rapid and sensitive deteetion of Escherichia coli 0151-Ml Anal. Chim. Acta, 687, 89-96. 

Yang et al. reported a capacitive immunosensor for the detection of Salmonella spp. based on grafted ethylene diamine and self-assembled AuNP monolayers on a glassy... 

Li et al. developed a label-free capacitive immunosensor for rapid and sensitive detection of E. coll 0157 H7. The immunosensor was fabricated by immobilizing affinity-purified anti-C. coll 0157 H7 antibodies onto SAMs of 3-mercaptopropionic acid (MPA) on the surface of a quartz crystal Au electrode activated by immersion in EDC/NHS solution to convert the terminal carboxylic group of MPA to an active NHS ester. Bacteria suspended in solution became attached to the immobilized antibodies when the immunosensor was tested in liquid samples. The change in capacitance caused by the bacteria was directly measured and an equivalent circuit was introduced to simulate the capacitive itnmunosen-sor (Figure 14.1 la). This consisted of ohmic resistance (R ) of the electrolyte double-layer capacitance (C i) including and Cqq, electron-transfer resistance (Ret), and War-... 

Yang, G.-J., Huang, J.-L., Meng, W.-J., Shen, M., and Jiao, X.-A. (2009) A reusable capacitive immunosensor for detection of Salmonella spp. based on grafted ethylene diamine and self-assembled gold nanoparticle monolayers. Anal Chim. Acta, 647, 159-166. 

Label-free capacitive immunosensor for microcystin-LR using self-assembled thiourea monolayer incorporated with Ag nanoparticles on gold electrode. Biosens. Bioelectron. 24, 78—86. 

---