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Cannabis dependence mechanisms

The analgesic properties of cannabinoid derivatives are well known, though no such drugs have yet been demonstrated to be substantially free from the CNS side effects to which cannabis sativa owes its popularity as a substance of abuse.However, cannabinoid analgesia has appeal due to its opioid-independent mechanism and its conseguent failure to induce dependence.A series of preliminary reports " have described the syntheses of analgesics modelled on 9-nor-9-B-hydroxyhexahvdrocannabinol compound Jl8 was the most potent member (>60 X morphine). ... [Pg.6]


See other pages where Cannabis dependence mechanisms is mentioned: [Pg.170]    [Pg.510]    [Pg.284]    [Pg.50]    [Pg.54]    [Pg.584]    [Pg.692]    [Pg.74]    [Pg.91]   


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