Cannabinoids immunologic

The CB2 gene has been associated with the risk for celiac disease [299], hepatic anomalies [300, 301], osteoporosis [302-304], and drug addiction [305]. An endophenotype consisting of reduced immune modulation may underlie some of these conditions. Risk for immunological compromise may be associated with the CB2 variants [298] suggesting that novel cannabinoid ligands could be developed to reverse this effect [304],... 

Kuwae, T., Shiota, Y., Schmid, PC., Krebsbach, R., Schmid, H.Fl.O., 1999. Biosynthesis and turnover of anandamide and other A-acylethanolamines in peritoneal macrophages. FEBS Lett. 459, 123-127. Lau, A.H. and Chow, S.S., 2003. Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells. Eur. J. Pharmacol. 464, 229-235. 

Suitable immunological reagents for the detection of cannabis abuse from urine tests are available from several companies. In normal circumstances, the sensitivity of a test corresponds to a cut-off value of 50 ng/ml based on 11-nor-A9-THC-9-carboxylic acid. The cut-off values of some cannabinoids are listed in Table 8-29. Only U-nor-A9-THC-9-carboxylic acid is relevant to the determination of consumption from urine tests. 

List of Commercially Available Cannabinoid Receptor Immunological Reagents Applicable to Cytochemical and/or Histocbemical Procedures... 

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