Cannabinoid receptor internalization

Howlett, A.C. et al., International Union of Pharmacology. XXVII. Classification of cannabinoid receptors, Pharmacol. Rev., 54, 161, 2002. 

When marijuana is ingested or inhaled, THC binds to cannabinoid receptors throughout the brain and body, where it mimics the actions of internally produced neurotransmitters, such as the endocannabinoid known as anandamide. Anandamide is named after the Sanskrit word ananda, which means bliss. ... 

Pertwee RG, Howlett AC, Abood ME et al (2010) International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands beyond CBi and CB2. Pharmacol Rev 62 588-631... 

Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K (1999) Distinct domains of the CBI cannabinoid receptor mediate desensitization and internalization. J Neurosci 19 3773-3780... 

Riegel AC, Williams JT, Lupica CR (2003) Cannabinoid receptor activation depresses GABAb-mediated synaptic responses in dopamine neurons. In 2003 Symposium on the cannabinoids. International Cannabinoid Research Society, Burlington, p 23... 

Malan TP, Ibrahim MM, Makriyannis A, Porreca F (2004) CB2 cannabinoid receptors may produce peripheral analgesia by stimulating local release of endogenous opioids. 2004 Symposium on the Cannabinoids. International Cannabinoid Research Society, p 52... 

Hsieh C, Brown S, Derleth C, Mackie K (1999) Internalization and recycling of the CBl cannabinoid receptor. J Neurochem 73 493-501... 

Wright K, Rooney N, Tate J, et al (2003) Functional cannabinoid receptor expression in human colonic epithelium. International Cannabinoid Research Society 13th Annual Symposium on the Cannabinoids, abstr 25... 

Kearn, C.S., Hilliard, C.J. (1997) Rat microglial cell express the peripheral-type cannabinoid receptor (CB2) which is negatively coupled to adenylyl cyclase. 1997 Symposium on the Cannabinoids, Burlington, Vermont, International Cannabinoid Research Society, 57. 

The normal internalization of the wild-type receptor, defined as a loss of cell surface receptors (measured by decreased maximal binding or B ), was unaffected for the desensitization-deficient Thr mutant (see Fig. 6.4C,D) but may have been affected when distal carboxyl terminal residues were mutated (see Fig. 6.3). Therefore some, although not all, GPCRs show radical dissociation between desensitization and internalization. This is found not only in the dopamine Dj receptor (122) but also in the N-formyl peptide (134), the CBl cannabinoid (17), and the M2 muscarinic (155) receptors. 

Bisogno T, Maione S, Valenti M, et al (2005b) FAAH inhibition elevates endocannabinoid levels in the periaqueductal grey of the rat dual effects on nociception via CBI and TRPVl receptors. XV Conference of the International Cannabinoid Research Society, Clearwater Beach, 24—27 June 2005. International Cannabinoid Research Society, Burlington, p 34... 

Kathmann M, Haug K, Heils A, Noth en M, Schlicker E (2000) Exchange of three amino acids in the cannabinoid CBI receptor (CNRl) of an epilepsy patient 2000 Symposium on the Cannabinoids. International Cannabinoid Research Society, Burlington, Vermont... 

Guanini F, Croci T, Aureggi G, Manara L, Rinaldi-Carmona M, Mukenge S, Aldrighetti L, Ferla G, Maffrand J-P, Le Fur G (2000) Tolerance to (+)WlN55,212-2 inhibitory effect and withdrawal by the cannabinoid CBl receptor antagonist SR 141716 in isolated strips of small intestine. International Cannabinoid Research Society symposium on the Cannabinoids, Burlington, Vermont... 

Coutts AA, Anavi-Goffer S, Ross RA, MacEwan DJ, Mackie K, Pertwee RG, Irving AJ (2001) Agonist-induced internalization and trafficking of cannabinoid CBl receptors in hippocampal neurons. J Neurosci 21 2425-2433... 

Sjogren S, Ryberg E, Lindblom A, Larrson N, Astrand A, Hjorth S, Andersson A-K, Groblewski T, and Greasley P (2005) A New Receptor for Cannabinoid Ligands, in 2005 Symposium on the Cannabinoids pp 106, International Cannabinoid Research Society, Clearwater, FL. 

Muthian, S. and Hillard, C. J. (2000). CBj receptor antagonists are neuroprotective in focal cerebral ischemia-reperfusion injury. Proceedings of the ICRS Symposium on the Cannabinoids. p. 107. International Cannabinoid Research Society. Burlington. 

Fride E, Ezra D, Suris R, Weisblum R, Blau H, Feigin C. 2003. Role of CBj receptors in newborn feeding and survival maintenance of ultrasonic distress calls and body temperature. 2003 Symposium on the Cannabinoids. Burlington, VT International Cannabinoid Research Society, p. 37. 

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