Cancer tumor suppressor genes

TABLE 5.22 Important Oncogenes and Tumor Suppressor Genes in Human Cancers... 

Adenomatous polyposis coli (APC) gene A tumor suppressor gene, acting as a gatekeeper to prevent development of tumors. A familial cancer syndrome called FAP, or familial adenomatous polyposis, is caused by mutations in APC. Mutation of APC also occurs commonly in sporadic cases of colorectal carcinoma. 

It has also been proposed that Parkin is a tumor suppressor gene [240]. It is included in the fragile site FRA6E [241] and down-regulation of Parkin protein due to exon duplication or deletions has been observed in several cancer cell lines and tumors [241]. 

Ho, A., Wakeham, A, Itie, A., Khoo, W., Fukumoto, M., and Mak, T.W., 1998, High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. S 1169-1178. 

Kim S, Chin K, Gray JW, Bishop JM (2004) A screen for genes that suppress loss of contact inhibition identification of 1NG4 as a candidate tumor suppressor gene in human cancer. Proc Natl Acad Sci USA 101 16251-16256... 

Canote R, Du Y, Carling T, Tian F, Peng Z, Huang S (2002) The tumor suppressor gene RIZ in cancer gene therapy. Oncol Rep 9 57-60... 

Although the study of inherited cancer syndromes has led to the identification of a number of tumor suppressor genes and oncogenes, the inherited cancer syndromes are thought to account for only about 1% of all cancers. However, somatic (as opposed to germline) mutations in many of these tumor suppressors and proto-oncogenes play a key role in the causation of noninher-... 

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