Cancer tumor components

With chromatin-remodeling complexes Involved in so many cases of transcriptional control. It Is expected that Swi/Snf and similar complexes will be linked to many cancers. In humans, for example, mutations In Brgl, which encodes the Swi/Snf catalytic subunit, have been found in prostate, lung, and breast tumors. Components of the Swi/Snf complex also have been found to associate with BRCAl, a nuclear protein that helps suppress human breast cancer. BRCA-1 Is Involved In the repair of double-strand DNA breaks (discussed In the final section of this chapter) and In transcriptional control, so the Swi/Snf complex may assist BRCA-1 In these functions. 

Fig. 10.11. Rectal wall invasion. Trans-axial T2-weighted image. A cystic and solid left ovarian cancer arrow) compresses bladder (B) and rectum (R).The latter shows broad contact with the solid tumor component located in the cul-de-sac. B, bladder...

Fig. 10.12. Pelvic sidewall invasion. Transaxial CT at the level of the iliac bifurcation. A mixed solid and cystic adnexal tumor, which was nondifferen-tiated ovarian cancer at histopathology, is located in the pelvis. The left pelvic sidewall, including iliac vessels and psoas muscle, are clearly separated by fat. The right pelvic sidewall (arrow) is in direct contact with the solid tumor component. Furthermore, external and internal iliac arteries are displaced, the latter is encased by tumor (arrowhead)...

Phytosterols have been demonstrated as being anti-cancer components in the diet (Awad and Fink 2000). Scientific studies indicate that phytosterols may offer profection against colon, breast and prostate cancers (Vanderhaeghe and Bouic, 2000). The possible mechanisms, as reported by these authors, include the effect of phytosterols on membrane structure and function and on the signal transduction pathways that regulate tumor growth and apoptosis. The rice bran derived phytosterol-cycloartenol-ferulic acid ester on the central nervous system has been studied by Hiraga et al. (1993). 

Kessel D (1982) Components of hematoporphyrin derivatives and their tumor-localizing capacity. Cancer Res 42 1703-1706. 

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