Cancer reactive oxygen species

Ushio-Fukai M, Nakamura Y (2008) Reactive oxygen species and angiogenesis NADPH oxidase as target for cancer therapy. Cancer Lett 266 37-52 Valentin A, Rosati M, Patenaude DJ, Hatzakis A, Kostrikis LG, Lazanas M (2002) Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy. Proc Natl Acad Sci U S A 99(10) 7015-7020... 

FEIG D I, REID T M and LOEB L A (1994) Reactive oxygen species in tumorigenesis . Cancer Res, 54, 1890s-4s. 

The protective effects of carotenoids against chronic diseases appear to be correlated to their antioxidant capacities. Indeed, oxidative stress and reactive oxygen species (ROS) formation are at the basis of oxidative processes occurring in cardiovascular incidents, cancers, and ocular diseases. Carotenoids are then able to scavenge free radicals such as singlet molecular oxygen ( O2) and peroxyl radicals particularly, and protect cellular systems from oxidation. 

Cancer is one of the diseases in which a role has been implicated (see Table 13.1) for free radicals. Comprehensive accounts of the involvement of reactive oxygen species in human diseases may be found in Halliwell and Gutteridge (1989), Aruoma (1993) and in Cheeseman and Slater (1993). 

Cui, Y., Lu, Z., Bai, L., Shi, Z., Zhao, W.E., and Zhao, B. 2007. Beta-carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. EurJ Cancer 43 2590-2601. 

The importance of superoxide-mediated damage to cancer cells was also demonstrated in the experiments with overexpressed mitochondrial MnSOD. Hirose et al. [186] showed that the overexpression of mitochondrial MnSOD enhanced the survival of human melanoma cells exposed to cytokines IL-1 and TNF-a, anticancer antibiotics doxorubicin and mitomycin C, and y-irradiation. Similarly, Motoori et al. [187] found that overexpression of MnSOD reduced the levels of reactive oxygen species in mitochondria, the intracellular production of 4-hydroxy-2-nonenal, and prevented radiation-induced cell death in human hepatocellular... 

Keywords Photodynamic therapy Photosensitizer Photochemistry Reactive oxygen species Cancer Microorganism Infection... 

Wagner, B. A., Buettner, G. R., Oberley, L. W., and Burns, C. P., 1998, Sensitivity ofK562 and HL-60 cells to edelfosine, an ether Upid drug, correlates with production of reactive oxygen species. Cancer Res. 58 2809-2816. 

D. Washo-Stultz, C. L. Crowley-Weber, K. Dvorakova, C. Bernstein, H. Bernstein, K. Kunke, C. N. Waltmire, H. Garewal and C. M. Payne, Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis. Cancer Lett., 2002, 177(2), 129. 

Ganguly A, Das B, Roy A, Sen N, Dasgupta SB, Mukhopadhayay S, Majumder HK. (2007) Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death. Cancer Res 67 11848-11858. 

Wiesman H, Halliwell B (1996) Damage to DNA by reactive oxygen species and nitrogen species role of inflammatory disease and progression to cancer. Biochem J 313 17-29... 

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