Cancer Immunological enhancement

We propose that these arguments are consistent with, but do not corroborate, the hypothesis that the platinum drug enhances the antigenic character of the tumor cells, tipping the balance in favor of the host s immunologic intervention to destroy the cancer. The question then becomes, how does the platinum drug accomplish this . Now we return to the derepression story based on Reslova s work. In brief, Fig. 7 outlines one potential sequence of molecular events in a mammalian cell which could produce the desired result. 

Tagawa S T, Lee P, Snively J, et al. (2003). Phase I study of intranodal delivery of a plasmid DNA vaccine for patients with Stage IV melanoma. Cancer. 98 144-154. Prud homme G J, Glinka Y, Khan A S, et al. (2006). Electroporation-enhanced non-viral gene transfer for the prevention or treatment of immunological, endocrine and neoplastic diseases. Curr. Gene. Ther. 6 243-273. 

Carson WE et al. Interleukin-2 enhances the natural killer cell response to Herceptin-coated Her2/ueu-positive breast cancer cells. European Journal of Immunology 2001 31 3016-3025. 

At the whole-body level, some population studies have indicated that certain carotenoids from either dietary intake or blood concentration data are associated with better immune response, lower rates of age-related macular degeneration (AMD) and cataract, as well as lower risk for certain cancers and cardiovascular disease. /d-Carotene may increase immunological functions by enhancing lymphocyte... 

---