Cancer, exogenous administration

Melatonin secretion is synchronized to the light/dark (LD) cycle, with a nocturnal maximum (in young humans, about 200 pg/ml plasma) and low diurnal baseline levels (about 10 pg/ml plasma). Studies have supported the value of the exogenous administration of melatonin in circadian rhythm sleep disorders, insomnia, cancer, neurodegenerative diseases, disorders of the immune function, and oxidative damage (Karasek et al. 2002 Pandi-Perumal et al. 2005, 2006 Srinivasan et al. 2005a,b, 2006 Hardeland et al. 2006). 

LHRH and selected synthetic analogues were developed for the treatment of conditions that necessitate a hypogonadal state (endometriosis, prostate or breast cancer) or to promote the descent of testicles in children 12-24 months old however, the pulsatile application of exogenous LHRH, for instance, by intranasal administration to healthy young men was shown to lead to a significant increase of the plasma... 

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