Cancer chemopreventive agent carcinogenesis test

So far, no potential cancer chemopreventive agent constituent from a Hernandia species has been subjected to biological follow up after the initial in vitro investigation, e.g., by using a mouse mammary organ culture assay [75] or a two-stage mouse skin carcinogenesis test [86]. 

As a continuation of our biological studies on potential cancer chemopreventive agents, we carried out primary screening and in vivo two-stage carcinogenesis test of several crude drugs which have been used for traditional medicines as crude extracts or decoctions of plural herbal medicines. 

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