Cancer alkyl sulfonate

The management of cancer includes treatment with alkylating agents (nitrogen mustards and alkyl sulfonates), antimetabolites (methotrexate and purine analogs), natural products (vinca alkaloids and antibiotics), miscellaneous compounds (hydroxyurea, procarbazine, and cis-platinum), hormones (estrogens and corticosteroids), and radioactive isotopes (see Chapter 62). 

Mailing to Sobels (October 1970), EMS. Ethyl methanesulfonate and methyl methane-sulfonate were standard alkylating agents used in routine chemical mutagenesis research. Cyclophosphamide, a known teratogen, was a compound used in cancer chemotherapy. 

Many chemicals in their unmetabolized form react directly with DNA or other cell constitnents, causing cancer. These substances are classed as primary carcinogens. Alkylating agents, ethylene oxide, peroxides, dimethyl sulfate, sulfones, sulfur mustards, and bis(chloromethyl)ether are examples of primary carcinogens. 

H. Hoppe IV, T. R. Skopek, H. L. Liber, and W. G. Thilly, Alkyl methane sulfonate mutation of diploid human lymphoblasts and Salmonella typhimurium. Cancer Res. 38, 1595 (1978). 

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