CAMP-receptor protein

Gorshkova, I., J.L. Moore, K.H. McKenney, and F.P. Schwarz. 1995. Thermodynamics of cyclic nucleotide binding to the cAMP receptor protein and its T127L mutant. J Biol Chem 270 21679-21683. 

Catabolite activator protein, CAP (also called cAMP receptor protein, CRP) is an activator required for high level transcription of the lac operon. The active molecule is a CRP dimer that binds 3 5 cyclic AMP to form a CRP-cAMP complex. CRP-cAMP binds to the lac promoter and increases the binding of RNA polymerase, stimulating transcription of the lac operon. CRP dimer without cAMP cannot bind to this DNA. The action of CRP depends upon the carbon source available to the bacterium. When glucose is present, the intracellular level of cAMP falls, CRP cannot bind to the lac promoter and the lac operon is only weakly transcribed. When glucose is absent, the level of intracellular cAMP rises, the CRP-cAMP complex stimulates transcription of the lac operon and allows lactose to be used as an alternative carbon source. 

CRP C-reactive protein also cAMP receptor protein... 

Eleyduk T, Lee JC. Escherichia-coli camp receptor protein - evidence for 3 protein conformational states with different promoter binding affinities. Biochemistry 1989 28 6914-6924. 

Elarman JG. Allosteric regulation of the cAMP receptor protein. Bba-Protein Struct. M 2001 1547 1-17. 

CMP Camp receptor protein (catabolite activator protein)... 

DNA-dependent RNA pol3merase 996 promoter 998 consensus sequence 998 cAMP receptor protein (CRP) 1001... 

See also Figure 9.1, Table 9.5, Figure 9.16a, cAMP Receptor Protein... 

See also Galactose Operon, Galactose Metabolism, Diastereomers, Saccharides, cAMP Receptor Protein, Monosaccharide Nomenclature... 

INTERNET LINK E. coli cAMP Receptor Protein... 

See also cAMP Receptor Protein, Arabinose Operon... 

See also Lactose Operon Regulation, cAMP Receptor Protein (CRP), RNA Polymerases... 

See also cAMP receptor protein (CRP), Lac Repressor, trp Operon Regulation, Arabinose Operon... 

Fig. 16.7. Catabolite repression of stimulatory proteins. The lac operon is used as an example. A. The inducer allolactose (a metabolite of lactose) inactivates the repressor. However, because of the absence of the required coactivator, cAMP-CRP, no transcription occurs unless glucose is absent. B. In the absence of glucose, cAMP levels rise. cAMP forms a complex with the cAMP receptor protein (CRP). The binding of the cAMP-CRP complex to a regulatory region of the operon permits the binding of RNA polymerase to the promoter. Now the operon is transcribed, and the proteins are produced.

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