Camostat

Bowman-Birk inhibitor [7,141,145], camostat mesilate (=FOY-305) [3,5,76], chicken ovoinhibitor [47], chicken ovomucoid [46], DFP [26], flavonoid inhibitors [149], human pancreatic trypsin inhibitor [48], leupeptin [3], p-aminobenzamidine [150], PMSF [151], poly(acrylate) derivatives [152], soybean trypsin inhibitor [5,7,46,51,78,141], TLCK (tosyllysine chloromethlyketone) [26]... 

Contrary to the above-mentioned inhibitors, FK-448 (4-(4-isopropylpiperadinocarbonyl) phenyl 1,2,3,4,-tetrahydro-l-naphthoate methanesulfonate) is a low toxic as well as a potent and specific inhibitor of chymotrypsin. The effectiveness of this substance as an intestinal absorption enhancer has already been demonstrated in rats as well as in dogs. Coadministra-tion of FK-448 led to an enhanced absorption of insulin, which was monitored by a decrease in blood glucose level. The inhibition of chymotrypsin was found to be mainly responsible for the enhanced bioavailability [3]. Camostat mesilate (A,A -dimethyl carbamoylmcthyl-/)-(//-guanidino-benzoyloxy)phenylacetate methanesulfonate) [5] and Na-glycocholate [5,27] are further representatives of this class, exhibiting low toxicity. 

Otsuki, M., et al. 1987. Effect of synthetic protease inhibitor camostat on pancreatic exocrine function in rats. Pancreas 2 164. 

Trypsin j>-Aminobenzamidine, antipain, aprotinin, Bowman-Birk inhibitor, camostat mesylate, chicken ovoinhibitor, chicken ovomucoid, human pancreatic trypsin inhibitor, soybean trypsin inhibitor,... 

Representatives of this class of inhibitors are DFP (diisopropylfluoro-phosphate), PMSF (phenylmethylsulfonyl fluoride), APMSF (4-aminophe-nyl)-methanesulfonyl, AEBSF (4-(2-aminoethyl)-benzenesulfonyl fluoride), FK-448 (4-(4-isopropylpiperadinocarbonyl) phenyl 1,2,3,4,-tetrahydro-1-naphthoate methanesulfonate), camostat mesilate (7V,/V -dimethyl carba-moylmethyl-/)-(/> -guanidino-benzoyloxy)phenylacetate methanesulfonate), and Na-glycocholate. The organophosphorus inhibitors DFP and PMSF are potent irreversible inhibitors of serine proteases. Due to their... 

Enzyme Inhibitors Amastatin, bestatin, camostat mesylate, boroleucine Enzyme inhibition... 

Classical enzyme inhibitors such as bacitracin, bes-tatin, and amastatin have been found to be effective for improving the nasal absorption of various peptide drugs such as LHRH and calcitonin. These inhibitors having peptide like structures appear to exert their inhibitory effects by a competitive mechanism. In addition, camostat mesilate and nafamostat mesilate, which are clinically used as primary ingredients for pancreatic diseases, have been found to improve the nasal absorption of vasopressin, desmopressin, and calcitonin by inhibiting aminopeptidase and trypsin activity. 

FOY 305 FOY 5980) is a guanidobenzoate derivative, an ENZYME INHIBITOR active as a (serine) PROTEASE INHIBITOR. It has a protective effect in animal models of pancreatitis, and has been used by mouth in human therapeutics, camostat mesilate camostat. cAMP cyclicAMP. 

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