Calmodulin sulfur mustard-induced

Rosenthal, D.S., Simbulan Rosenthal, C.M., Iyer, S., Spoonde, A., Smith, W., Ray, R., and Smulson, M.E. (1998). Sulfur mustards induces markers of terminal differentiation and apoptosis in keratinoc)4es via a Ca -calmodulin and caspase-dependent pathway. J Invest Dermatol 111, 64-71. 

Calmodulin, poly(ADP-ribose)polymerase and p53 are targets for modulating the effects of sulfur mustard (Rosenthal et al, 2000). It was tested whether calmodulin mediates the mitoehondrial apoptotic pathway induced by SM in human keratinoeytes. Of the three human CaM genes, the predominant form expressed was CaMl. These results indicate that CaM, ealeineurin, and Bad also play a role in SM-induced apoptosis, and may therefore be targets for therapeutic intervention to reduce SM injury (Simbulan-Rosenthal et al, 2006). 

Kadar T, Fishbeine E, Meshulam Y et al. (2000). Treatment of skin injuries induced by sulfur mustard with calmodulin antagonists, using the pig model. J Appl Toxicol, 20, S133—S136. 

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See also in sourсe #XX -- [ ]

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