Calcium homeostasis abnormal intracellular

In a series of studies, Dubovsky et al. ( 34) measured intracellular calcium ion concentrations in bipolar manic and depressed patients. They found decreases in mean concentrations in four bipolar, manic, and five bipolar, depressed, patients, in comparison with seven normothymic subjects without personal or first-degree relative histories of psychiatric disorders. Their findings were consistent with a diffuse abnormality in the mechanisms modulating intracellular calcium homeostasis. Further, this phenomenon s presence in both platelets and lymphocytes lends credence to a disruption in the cell membrane, the G-protein, or other mechanisms involved in the homeostasis of intracellular calcium ion concentrations. This may also support an extension of their findings from peripheral to neuronal tissue. 

Missiaen L., Robberecht W., van den Bosch L., Callewaert G., Parys J.B., Wuytack F., Raeymaekers L., Nilius B., Eggermont J., and De Smedt H. 2000 Abnormal intracellular Ca2+ homeostasis and disease. Cell Calcium 28, 1-21. 

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