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Calcium channel blockers categories

Four categories of calcium channel blockers can be defined based on their chemical structures and actions diphenylalkylamines, benzothiazepines, dihydropyridines, and bepridil. Both diphenylalkylamines (verapamil) and benzothiazepines (diltiazem) exhibit effects on both cardiac and vascular tissue. With specificity for the heart tissue, these two types of calcium channel blockers can slow conduction through the AV node and are useful in treating arrhythmias. The dihydropyridines (nifedipine is the prototypical agent) are more potent peripheral and coronary artery vasodilators. They do not affect cardiac conduction, but can dilate coronary arteries. They are particularly useful as antianginal agents. Bepridil is unique in that it blocks both fast sodium channels and calcium channels in the heart. All calcium channel blockers, except nimodipine and bepridil, are effective in treating HTN. [Pg.21]

Category Antiarrhythmic class IV Calcium channel blocker Half-life 30-50 hours... [Pg.31]

Trade name Cleviprex (The Medicines Company) Indications Reduction of blood pressure Category Calcium channel blocker Half-life Initial I Minute Terminal 15 Minutes... [Pg.133]

Trade names Alti-Diltiazem Britiazem Calcicard Cardizem (Biovail) Cartia-XT Deltazen Dilacor XR (Watson) Dilrene Diltahexal Diltia-XT Nu-Diltiaz Presoken Teczem (Sanofi-Aventis) Tiamate Tiazac (Forest) Tilazem Tildiem Indications Angina, essential hypertension Category Antiarrhythmic class IV Calcium channel blocker Half-life 5-8 hours (for extended-release capsules)... [Pg.183]

Trade names AGON SR Hydac Lexxel (AstraZeneca) Modip Munobal Penedil Plendil (AstraZeneca) Renedil Splendil Indications Hypertension Category Calcium channel blocker Half-life I 1-16 hours... [Pg.230]

Indications Analgesic, severe chronic pain Category Neuronal calcium channel blocker Half-life 4.6 hours... [Pg.622]

As a category of medications, calcium channel blockers are contraindicated in a client diagnosed with CHF however, the calcium channel blocker Norvasc is an exception it alone among the calcium channel blockers has been shown not to reduce life expectancy. Norvasc may be given to the client safely. [Pg.57]

The calcium channel antagonists comprise the type EV antiarrhythmic category. At least two types of calcium channels are operative in SA and AV nodal tissues an L-type channel and a T-type channel. Therefore, both L-channel blockers (verapamil and diltiazem) and selective T-channel blockers (mibefradil—previously approved but withdrawn from the market) will slow conduction, prolong refrac-... [Pg.328]

Calcium-entry blockers include those agents that are selective for slow calcium channels in the myocardium (slow-channel blockers), and consist of the following categories of substances ... [Pg.121]

Calcium-entry blockers include those agents that are selective for slow calcium channels in the myocardium (slow channel blockers) and consist of the following categories of substances benzothiazepines (diltiazem and dihydropy-ridines)—nifedipine, nicardipine, niludipine, nimodipine, nisoldipine, nitrendipine, ryosidine, amlodipine, azodipine, dazodipine, felodipine, flordipine, iodipine, isradipine, mesu-dipine, oxodipine, and riodipine and, phenylalkylamines— verapamil, gallopamil, anipamil, desmethoxyverapamil, emopamil, falipamil, and ronipamil. [Pg.204]

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See also in sourсe #XX -- [ Pg.21 ]



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