Calcium/cAMP response element binding

Mao L, Wang JQ (2002) Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors. Mol Pharmacol 62 473-484. 

CaMKIV is responsible for calcium-dependent gene transcription through the phosphorylation of transcription factors cAMP response element-binding protein (CREB), serum response factor (SRF), and myocyte enhancer factor-2 (MEF2). Oncoprotein 18 in the cytoplasm is also a substrate of CaMKIV. The activity of CaMKIV is activated by CaMKK and autophosphorylation. The elongation factor-2 is the only known substrate of CaMKIII (eEF-2K) at present. The phosphorylation of elongation factor-2 inhibits its functions. 

Calcium-calmodulin-dependent protein kinase IV cAMP response element cAMP-responsive element-binding protein C Cerebrospinal fluid Dentate gyms... 

Quantitatively, the binding of Ca2+ to the glycocalyx is of secondary importance compared to that bound by phospholipid elements. The glycocalyx does play a significant role in the determination of myocardial cell Ca2+ permeability (20, 21). Upon arrival of the appropriate electrical stimulus T ction potential), Ca2+ crosses the sarcolemma and is the principal cation responsible for a current called the "slow inward current" (lsi) (3-2, 22, 23, 24). Calcium is conducted across the sarcolemma through channels or pores which are controlled by the phosphorylation of sarcolemmal and sarcotubular proteins. Cardiac sarcolemma and sarcoplasmic reticulum are phosphorylated by exogenous and endogenous cyclic adenosine 5 -5 - monophosphate (cAMP)-dependent protein kinases (25, ... 

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