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Calcimimetic agent

Cinacalcet is a calcimimetic agent that modulates the response of the calciumsensing receptor on the parathyroid gland, and thus may lead to a reduction in the levels of calcium. It is marketed to treat hypercalcemia (Figure 8.83). [Pg.331]

This rather common disease, if associated with symptoms and significant hypercalcemia, is best treated surgically. Oral phosphate and bisphosphonates have been tried but cannot be recommended. Asymptomatic patients with mild disease often do not get worse and may be left untreated. The calcimimetic agent cinacalcet, discussed previously, has been approved for secondary hyperparathyroidism and is in clinical trials for the treatment of primary hyperparathyroidism. If such drugs prove efficacious, medical management of this disease will need to be reconsidered. [Pg.968]

Dong BJ. Cinacalcet An oral calcimimetic agent for the management of hyperparathyroidism. Clin Ther. 2005 27 1725-1751. [Pg.473]

Collins MT, Skarulis MC, Bilezikian JP, et al. Treatment of hypercalcemia secondary to parathyroid carcinoma with a novel calcimimetic agent. J CUn Endocrinol Metab 1998 83 1083-1088. [Pg.966]

Franceschini N, Joy MS, Kshirsagar A. Cincacet HCl a calcimimetic agent for the management of primary and secondary hyperparathyroidism. Expert Opin Investig Drugs 2003 12 1413-1421. [Pg.966]

Cinacalcet is a calcimimetic agent that lowers parathyroid hormone (PTH) levels by increasing sensing receptor to extracellular calcium. This drug is indicated in the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and hypercalcemia in patients with parathyroid carcinoma. [Pg.157]

Cinacalcet is the first type II calcimimetic agent approved that improves CaSR sensitivity to calcium (19,50). When calcium is bound to the CaSR, phospholipase C is activated, and the secretion of PTH is inhibited. In the presence of cinacalcet, not only is a drop in ... [Pg.1425]

Lalonde, R. et al., Mixed-effects modeling of the pharmacodynamic response to the calcimimetic agent R-568, Clin. Pharmacol. Ther., 65 40-49, 1999. [Pg.54]

See other pages where Calcimimetic agent is mentioned: [Pg.268]    [Pg.160]    [Pg.162]    [Pg.164]    [Pg.471]    [Pg.341]    [Pg.426]    [Pg.738]    [Pg.533]    [Pg.1699]    [Pg.840]    [Pg.955]    [Pg.1425]    [Pg.37]    [Pg.720]   
See also in sourсe #XX -- [ Pg.37 ]



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Calcimimetic

Calcimimetics

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