Caenorhabditis activated oncogenes

Figure 39 Activated Oncogenes in the Caenorhabditis Embryo (the Dauer State). Unopposed Replication of Undifferentiated Epithelial Stem Cells Kill the Adult Nematode. (Caenorhabditis elegans hermaphrodite adult). http //en.wikipedia.org/wild/File Caenorhabditis elegans hermaph-rodite adult-en.svg by KDS444 http //commons.wikimedia.Org/wild/User KDS444 is licensed under CC BY-SA 3.0 http //creativecommons.Org/licenses/by-sa/3.0/) Reference Appendix 2, Explanations to the Figures...

The mitochondrial control of cell fate in vertebrates involves interactions among proteins of the B cell lymphoma-2 (Bcl-2) proto-oncogene family, which has been functionally conserved throughout metazoan evolution. Its involvement in programmed cell death was first described in Caenorhabditis elegans, where it was shown that expression of ced-4 was required for cell death activation, whereas ced-9 overexpression maintained cell viability by suppressing interactions between the products of ced-4 and downstream cell death executioner proteins109. 

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