Cadiot-Chodkiewicz active template synthesis

Example 4, Cadiot-Chodkiewicz active template synthesis of rotaxanes and switchable molecular shuttles with weak intercomponent interactions ... 

The Cadiot-Chodkiewicz Active Template Synthesis of the [2]Rotaxane 74... 

Recently, Leigh et al. [189] prepared the [2]rotaxane 74 by the Cu-mediated Cadiot-Chodkiewicz active-metal template strategy (Scheme 9.25). The mechanically interlocked structure 74 was obtained in a high yield on crosscoupling of the bromoacetylene 75 with the terminal alkyne 76, both of which contained bulky end-capping groups. The cmdal step in the synthesis of 74 was... 

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