C-Silylation of Drugs

In contrast to 0- and N-silylated compounds, C-silylated drugs are relatively stable against hydrolytic decomposition. For this reason, they have no importance as prodrugs so far. 

These few examples illustrate that C-silylation of drugs can also lead to interesting biological properties, which can be similar or different as compared to the parent compounds. C-silylation of bioactive organic compounds may become a routine method in the development of novel drugs. 

5 Bioactive Silicon Compounds without Organic Analogues 

However, synthesis and biological screening of hundreds of novel silicon containing compounds resulted in the discovery of a large number of interesting bioactive framework structures, from which only a few characteristic examples are represented in this chapter. 

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