C-L Sinks Reacting with Common Sources

4 p3 C-L SINKS REACTING WITH COMMON SOURCES 8.4.1 Lone Pair Sources Reacting with sp3 C-L 

The substimtion versus elimination decision is considered in depth in Section 9.5. 

S-adenosylmethionine is the primary biochemical methyl group donor and provides an excellent example of a biological Sjs[2 reaction (Fig. 8.2). 

2 Bases Reacting with sp3 C-L Having an Adjacent CH, Eiiminations 

The different elimination paths often produce different alkene constitutional isomers as products regiochemistry). For the E2 reaction the C-H bond and the C-L bond must lie in the same plane, preferably anti to each other for steric reasons. The protons, shown in bold, on either carbon adjacent to the leaving group can be in proper alignment for reaction thus different products are produced (the cis product is also formed). 

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Section 8.4 sp C-L Sinks Reacting With Common Sources SnI example (hindered site) with follow-up proton transfer ... 

Section 8.4 sp C-L Sinks Reacting With Common Sources... 

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