C 1 esterase inhibitor

Bromfed pseudoephedrine, brompheniramine c 1 -esterase inhibitor Berinert, Cinryze ... 

Protease inhibitors TIMP-1, TIMP-2, plasminogen activator inhibitor-1, C-1 esterase inhibitor... 

U. Gottstein, D. J. Yoo and H. Buettner, C 1-Esterase und C 1-Esterase-Inhibitor im Serum von Kranken mit hereditdrem genuinem Quincke-Odem, Klin. Wschr. 45, 231-235 (1967). 

Kallikrein, which activates prourokinase, is inhibited by complement I1 esterase inhibitor (C 1-INH). 

Despite cases of transmission of hepatitis C associated with intravenous immunoglobulin in the 1990s, no cases of transmission of hepatitis, HIV, or Creutzfeldt-Jakob disease have since been reported with immunoglobulins [6 J. Before 1996, PCCs (prothrombin complex concentrates) were associated with minimal risk of transmission of infective agents [7 ]. There are no documented cases of viral transmission in patients with von Willebrand disease or hemophilia A treated with Haemate P/Humate P in over 25 years of clinical experience in Europe and more than 17 years in the USA [ ]. In the IMPACT-1 and IMPACT-2 trial in 124 patients there were no cases of HIV, hepatitis, or human B19 virus conversion. Furthermore, no cases of viral transmission have been reported during 30 years of post-marketing surveillance of Cl-esterase inhibitor concentrate [9, 10 ]. 

Craig TJ, Bewtra AK, Bahna SL, Hurewitz D, Schneider LC, Levy RJ, et al. Cl esterase inhibitor concentrate in 1085 hereditary angioedema attacks-final results of the 1.M.P.A.C.T.2 study. Allergy December 2011 66(12) 1604-11. 

Some 1-carbonyl-3-methyl-2-pyrazoline-4,5-dione-4-arylhydrazones are active against Trichinella spiral is. 3 Against microfilarial infections, 2-ethyl-6-methyl-2,3,4,4a,5,6,7,8-octahydro-lH-pyrazino(l,2-c)pyrimidine-l-one seems to be very promising.0,0-Dimethyl-2,2,2-trichloro-l-hydroxyethylphosphonate, a choline esterase inhibitor, immobilizes the adult Onchocerca volvulus and consequently is useful in treating onchocerciasis. 1 8... 

We proposed a metabohc pathway of phosphonates with structure lo in plants when these compounds lo were initially designed. lo might be metabolized to substituted phenoxyacetic acids (lo-a) as auxin-type herbicide and acylphospho-nates (lo-c) as PDHc El inhibitors after the hydrolysis and oxidation by esterases and oxidases took place in plants (Scheme 1.21). 

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