Butylated hydroxytoluene metabolism

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Mizutani, T. Yamamoto, K. Tajima, K. Isotope effects on the metabolism and pulmonary toxicity of butylated hydroxytoluene in mice by deuteration of the 4-methyl group. Toxicol. Appl. Pharm. 1983, 69, 283-290. 

Wiebel, F.J., and Waters, H.L. Effect of Butylated Hydroxytoluene and Hydroxyanisole on Benzo(a)pyrene Metabolism and Binding. In J.R. Fouts and I. Gut (eds.). Industrial and Environmental Xenobiotics, pp. 258-260. Amsterdam Excerpta Medica, 1978. 

Butylated hydroxytoluene is readily absorbed from the gastrointestinal tract and is metabolized and excreted in the urine mainly as glucuronide conjugates of oxidation products. Although there have been some isolated reports of adverse skin reactions, butylated hydroxytoluene is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant. ... 

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