Butyl hydroxyl anisole

Biotransformation of (-)-nopol benzyl ether (455 ) was carried out at 30°C for 8-13 days at the concentration of 277 mg/200 mL medium by A. niger TBUYN-2, A. sojae IFO 4389, and A. usami IFO 4338. (-) Nopol benzyl ether (455 ) was biotransformed by A. TBUYN-2 to give 4-oxo-nopol-2, 4 -dihydroxy benzyl ether (456 ), and ( )-oxonopol (454 ). 7-Hydroxymethyl-l-/ -menthen-8-ol benzyl ether (457 ) was not formed at all (Figure 19.185). 4-Oxonopol-2, 4 -dihydroxybenzyl ether (456 ) shows strong antioxidative activity (IC50 30.23 pM). The antioxidative activity of 4-oxonopol 2, 4 dihydroxybenzyl ether (456 ) is the same as that of butyl hydroxyl anisole (BHA) (Noma and Asakawa, 2006b,c). 

Figure 2.15 Working curves for room temperature fluorescence (1) butylated hydroxyl anisole ( ), (2) Agerite Superlite (O), (3) Nonox Cl (x)...

Oxonopol-2 ,4 -dihydroxybenzyl ether (456 ) shows strong antioxidative activity (IC50 30.23 iM). Antioxidative activity of 4-oxonopol-2 ,4 -dihydroxybenzyl ether (456 ) is the same as that of butyl hydroxyl anisol (BHA) (Noma and Asakawa, 2006b,c). 

Aromatic alcohols are called phenols. The simplest phenol, also called phenol, forms when a hydroxyl group replaces a hydrogen atom in the benzene ring. Phenol (carbolic acid) was used as an antiseptic in the 1800s. Today other phenol derivatives are used in antiseptic mouthwashes and in cleaning disinfectants such as Lysol. Phenols are easily oxidized, and this makes them ideal substances to use as antioxidants. By adding phenols such as BHT (butylated hydroxy toluene) and BHA (butylated hydroxy anisole) to food, the phenols oxidize rather than the food. 

This process has been studied in aqueous systems using probes (butyl chloride, nitrobenzene, and anisole) specific for hydroxyl radicals. The... 

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