Butyl flufenamate

Molecular formula C18H18F3NO2 Molecular weight 337.34 CAS Registry No 67330-25-0 Merck Index 13,4158 

Sample preparation Add 100—300 mg gel ointment to 3 mL MeOH, mix vigorously, filter (0.2 Am), inject a 10 lL aliqnot. 

Yamamura, K. Yamada, J.-L Yotsuyanagi, T. High-performance liquid chromatographic assay of antiinflammatory drugs incorporated in gel ointments. Separation and stability testing, J.Chromatogr., 1985, 331, 383-388. 

Molecular formula C14H14N4O2S Molecular weight 302.36 CAS Registry No 26097-80-3 Merck Index 13,1733 

Matrix abomasal fluid, blood, duodenal fluid, rumen fluid 

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Butyl flufenamate is a topical, non-steroidal antiinflammatory agent indicated for the treatment of acute and chronic eczema contact, seborrheic, and atopic dermatitis and herpes zoster. 

A number of compounds activate TRPA1 without any apparent ability to form covalent adducts, including nonelectrophilic fenamate nonsteroidal anti-inflammatory drugs (NSAIDs), such as flufenamic acid (17, FFA), niflumic acid (18, NFA), and mefenamic acid (19, MFA) [13]. Phenols such as thymol (20) and 2-ferf-butyl-5-methylphenol (21) have been shown to activate human TRPA1 with micromolar EC50 values in stably transfected HEK293 cells [14]. 

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