Burning feet syndrome

Deficiency is well documented in chickens, which develop a pantothenic acid-responsive dermatitis. Other experimental animals show a variety of abnormalities from pantothenic acid deficiency. In human beings dietary deficiency has not been reliably documented, although it has been implicated in the burning foot syndrome (nutritional melalgia). Subjects maintained on pantothenic acid-deficient diets or given the antagonist [Pg.345]

Human Pantothenic Acid Deficiency - The Burning Foot Syndrome... 

Neuromotor disorders, including paresthesia of the hands and feet, hyperactive deep tendon reflexes and muscle weakness. These can be explained by the role of acetyl CoA in the synthesis of the neurotransmitter acetylcholine and the impaired formation of threonine acyl esters in myelin. Dysmyelination may explain the persistence and recurrence of neurological problems many years after nutritional rehabilitation in people who had suffered from burning foot syndrome. 

Pantothenic acid Functional part of CoA and acyl carrier protein fatty acid synthesis and metabolism Peripheral nerve damage (burning foot syndrome)... 

DEFICIENCY SYMPTOMS. A deficiency of pantothenic acid has been associated with the "burning foot syndrome" that occurred in Japan and the Philippines among prisoners during World War II. 

---