Bupropion Antihistamines

Bupropion should not be administered with sedating antihistamines because of the increased risk of seizures. Bupropion is used for smoking cessation therapy and may cause insomnia as a side-effect. Patients are advised to avoid taking bupropion dose at bedtime. 

Bupropion, the only marketed aminoketone antidepressant, also has a side-effect profile different from the other classes of antidepressants. It is essentially devoid of anticholinergic, antihistaminic, and orthostatic hypotensive effects. Its principal adverse effects are consistent with its indirect agonism of dopamine and NE via uptake inhibition and include the following ... 

Although the mechanism of antidepressant action for bupropion is unclear, in vitro binding studies show bupropion to be a selective inhibitor of dopamine reuptake at the dopamine presynaptic neuronal membrane and minimal inhibition of NE and 5-HT reuptake (Table 21.2). Bupropion does not exhibit clinically significant anticholinergic, antihistaminic, ai-adrenergic blocking activity, or MAO inhibition. 

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