Bullous pemphigoid antigen hemidesmosomes

Westgate, G. E., Weaver, A. C., and Couchman, J. R. (1985). Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes. J. Invest. Dermatol. 84, 218-224. 

Dillman et al. (2003) have recently shown that sulphur mustard causes keratin 14 and keratin 5 to clump into stable aggregates. These appear within 15 min of exposure to sulphur mustard. It was noted that a number of blistering disorders (epidermolysis bullosa simplex and epidermolytic hyperkeratosis) are associated with abnormalities of these keratin molecules (Fuchs et al, 1994). The role of keratin 14 in linking to plectin (another component of the hemidesmosomes) and to the bullous pemphigoid antigen le was also noted. Werrlein and Madren-Whalley (2000) demonstrated that sulphur mustard reduced expression of keratin 14... 

Pulkkinen, L., Ditto, J., 1998. Hemidesmosomal variants of epidermolysis bullosa. Mutations in the alpha6beta4 integrin and the 180-kD bullous pemphigoid antigen/type XVII collagen genes. Exp. Dermatol. 7,46-64. 

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