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Bufa-20,22-dienolides

A novel substance with a bufadienolide-related chemical structure has been isolated from B. marinus skin. This substance is 3P-hydroxy-ll, 12-seco-5p, 14P-bufa-20, 22-dienolide-l 1, 14-olides-12oic acid (called marinoic acid) and shows the Na+/K+-ATPase inhibitory activity characteristic of the bufadienolides (Matsukawa, Akizawa, Morris, Butler Jr and Yoshioka 1996). [Pg.412]

Pettit et al and Engel et al. have recently developed successful syntheses of a bufadienolide. In both cases the final step involved dehydrogenation of a bufa-20(21)-enolide (1) to a bufa-20,22-dienolide (2). Both laboratories first tried... [Pg.140]

Resibufogenin, (30,50,150>-I4,ls-Epoxy-3-kydr-oxy-5-bufa-20,22-dienolide Respigon. CMHJ204 mol wt 384.50. C 74.97%, H 8.39%, O 16.65%. Cytotoxic constituent of toad venom. Isoln Meyer, Helv. Chim, Acta 35, 2444 (1952) Linde, Meyer, Pharm, Acta Helv. 33, 327 (1958). Structure Thiessen, Chem. Ind. (London) 1988, 440 ... [Pg.1296]

S-Acetoxy-14,15j6-epoxy-3/8-hydroxy-5y3,14i5-bufa-20,22-dienolide (cinobufagin) 38.1... [Pg.177]

Bufadlenolldes (5j3-bufa-20,22-dienolides). General name for compounds with the steroid basic skeleton shown in the formulae with cis-linkage of rings A and B (5 ff) and C and D (l4pH) as well as 17/3-oriented a- pyrone group. The (20/ )-20,21,22,23-tetrahydro compound is known as 5j3-bufanolide. B. are related to the cardenolides in their chemistry and biological activities. Compounds with this basic structure occur... [Pg.94]

See other pages where Bufa-20,22-dienolides is mentioned: [Pg.342]    [Pg.315]    [Pg.325]    [Pg.247]    [Pg.527]    [Pg.528]    [Pg.528]    [Pg.528]    [Pg.528]    [Pg.158]    [Pg.163]    [Pg.176]    [Pg.176]    [Pg.176]    [Pg.176]    [Pg.189]    [Pg.454]    [Pg.454]   
See also in sourсe #XX -- [ Pg.83 , Pg.274 ]



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