Buddlejaceae

Buddleja globosa Hope (Buddlejaceae) from Chili has been utilized for wound healing and treatment of ulcers. A sesquiterpene compound called buddledin A was isolated from the plant and showed dual inhibitions of COX with IC50 =13.7 pM and of 5-LOX with lC5o= 50.4 pM [136]. 

Crocetin monogentiobiosyl ester (carotenoid sugar ester) Buddleja officinalis (Buddlejaceae), Crocus spp. (Iridaceae) [flower] COX... 

Many sesquiterpene lactones are toxic to fish (Pieman, 1986a). Buddlejin A, B, and C (115,116, and 117) possess a caryophyllane skeleton and are piscicidal (Fig. 21.24). These compounds are found in Buddleja davidii (Buddlejaceae)... 

The water extract of Buddieja qfficinalis (Buddlejaceae) inhibited vascular inflammation and atherosclerotic disorders. Recently, Tai et al. isolated several compounds from the flowers of the plant and tested their in vitro effects on the proliferation of rat aortic vascular smooth muscle cells (VSMCs). Among the tested compounds, two iridoids, namely, methylscutelloside (146) and methylcatalpol (147), showed significant inhibitory effects on homodimer platelet-derived growth factor beta polypeptide (PDGF-BB)-induced proliferation in rat aortic VSMCs. Methylscutelloside (146) decreased cell proliferation at 10, 30, and 50 pM, with inhibition of 39.1%, 42.0%, and 79.6%, respectively, while methylcatalpol showed significant inhibition (80%) only at 50 pM concentration. Their inhibitory effect on rat aortic VSMC proliferation may be useful for the treatment of atherosclerosis [153]. 

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