Bryostatin analogues

Obviously, the access to the A, B and C ring fragments is the key to a successful synthesis of bryostatins. Therefore, next to the total syntheses several partial syntheses [18] and preparations of ring fragments are reported [19], These partial structures are also valuable components regarding the synthesis and evaluation of bryostatin analogues. 

Wender PA, Hinkle KW, Koehler ME, Lippa B. The rational design of potential chemotherapeutic agents synthesis of bryostatin analogues. Med. Res. Rev. 1999 19 388-407. 

Trost, B.M., Yang, H.,Thiel, O.R., Frontier, A.J. and Brindle, C.S. (2007) Synthesis of a ring-expanded bryostatin analogue. Journal of the American Chemical Society, 129, 2206-2207 Cook, C Guinchard, X., Liron, F. and Roulland, E. (2010) Total synthesis of (-)-exiguolide. Organic Letters, 12, 744-747. 

Wender, P.A. and Hinkle, K.W. (2000) Synthesis and biological evaluation of a new class of bryostatin analogues the role of ihe C20 substituent in protein kinase C binding. Tetrahedron Lett., 41, 6725-6729. 

Wender, P.A., de Brabander, J., Harran, P.G., Hinkle, KW., Lippa, B., and Pettit, G.R. (1998b) Synthesis and biological evaluation of fully synthetic bryostatin analogues. Tetrahedron Lett., 39, 8625-8628. 

Wender, P.A., Lippa, B., Park, C.-M., Irie, K, Nakahara, A., and Ohigashi, H. (1999) Selective binding of bryostatin analogues to the cysteine rich domains of protein kinase C isozymes. Bioorg. Med. Chem. Lett., 9, 1687-1690. 

Wender, P.A., DeChristopher, B.A., and Schrier, A.J. (2008) Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy. /. Am. Chem. Soc., 130, 6658-6659. 

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