Browning, Horace

A new method of determining the presence of tyrosine by bromina-tion was introduced by Horace Brown and employed by Adrian Brown and Millar in 1906 for estimating the rate at which tyrosine is split off from proteins by the action of trypsin. This method might be used for the estimation of tyrosine in proteins its non-employment may be due to the fact that tryptophane and also histidine react with bromine and might thus vitiate the result for tyrosine. 

J.B.F. (1925). Obituary notices of Fellows deceased Horace Tabberer Brown, 1848-1925. Proceedings of the Royal Society of London, Series A 109 xxiv—xxvii. 

See, for example, Petrus Abbonus, De Venenis, trans. Horace M. Brown, Annals of Medical History 6 (1924), 25-37 also Ambroise Pare, Of Poysons, The Workes of that famous Chirurgion Ambroise Parey, trans. Thomas Johnson (London, 1634), 775-815. Although it was a medieval text, De Venenis was regularly reprinted throughout the Renaissance and remained the primary toxicological authority. 

The group remaining at Burton included Horace Brown, Cornelius O Sullivan and Peter Greiss. Greiss was mostly noted for his work on... 

These views, and the research on which they were based, were part of the mainstream of organic chemistry. The nature of enzyme action was also by this time an important topic for research in its own right. The developments which eventually led to the Michaelis-Menten theory were ones in which Adrian Brown, his elder brother Horace, and others from the group at Burton-on-Trent all played a major part (Boyde, 1980 Teich and Needham, 1992). Curiously, in their publications, the word catalysis itself is conspicuous by its absence. 

Armstrong, H. E. (1937). Horace Brown Memorial Lecture. J. Inst. Brewing, 43, 375-86. 

Horace D. Brown, Marianne Costlow, Frank A. Cutler, Jr., Albert N. Demott, Walter B. Gall, David P. Jacobus, and Charles J. Miller "The Computer-Based Chemical Structure Information System of Merck Sharp Dohme Research Laboratories", J. Chem. Inf. and Computer Sci., 16. 5 (1976). 

---