Bronchodilators in COPD

As with other bronchodilators in COPD, parameters other than objective measurements such as FEVj should be monitored to assess efficacy. Subjective parameters, such as perceived improvements in dyspnea and exercise tolerance, are important in assessing the acceptability of methylxanthines for COPD patients. 

Inhaled anticholinergics are the most effective class of bronchodilators in COPD patients. Muscarinic receptors are localised to smooth muscle of all airways, but the density decreases down the respiratory tract. They are also localised to airway epithelium and submucosal glands [3]. Four subtypes of muscarinic receptors exist in the lungs and... 

Jara M, Wentworth C, Lanes S. A new user cohort study comparing the safety of long-acting inhaled bronchodilators in COPD. BMJ Open... 

---