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Bromopropionate

Ethyl a-bromopropionate. This preparation illustrates the facile bromination of an acid chloride (propionyl chloride) in the presence of red phosphorus, and the subsequent conversion of the bromoacid chloride into the ethyl ester by direct interaction with ethanol. [Pg.430]

Chapter III. 1 Heptene (111,10) alkyl iodides (KI H3PO4 method) (111,38) alkyl fluorides (KF-ethylene glycol method) (111,41) keten (nichrome wire method) (111,90) ion exchange resin catalyst method for esters (111,102) acetamide (urea method) (111,107) ethyl a bromopropionate (111,126) acetoacetatic ester condensation using sodium triphenylmethide (111,151). [Pg.1191]

Alkyl ketones can be prepared by the carbonylation of alkyl iodides in the presence of organoboranes. The carbonylation of iodocyclohexane with 9-octyl-9-BBN at 1 atm gives cyclohexyl octyl ketone in 65% yield[386]. This reaction is treated in Section 1.1.3.3. Methyl o-methylacetoacetate (919) is obtained by the reaction of the 2-bromopropionate 918, which has a /9-hydrogen, with CO and Me4Sn. PhjAs as a ligand gives better results than Ph3P[771]. [Pg.263]

Similarly, 5-thiazole alkanoic acids and their salts are obtained from thioamides and /3-halo -y-keto acids (695). Thus thioarylamides condensed with 3-aroyl-3-bromopropionic acid (88) in isopropanolic solution in the presence of Na COs give first 4-hydroxy-2-aryl-A-2-thiazoline-5-acetic acid intermediates (89), which were dehydrated in toluene with catalytic amounts of p-toluene sulfonic acid to 2,4-diaryl-5-thiazole acetic acid (90) (Scheme 39) (657), with R = H or Me Ar = Ph, o-, m- or p-tolyl, o-, m-, or P-CIC6H4, 0-, m-, or p-MeOC(iH4, P-CF3C6H4, a-thienyl, a-naphthyl (657). [Pg.208]

Butyl acrylate has been prepared by direet esterifieaLion/ by debromination of -butyl ,/3-dibromopropionate with zinc, by treatment of either butyl /3-chloropropionate or butyl /3-bromopropionate with diethylaniline, and by the pyrolysis of butyl (3-acetoxypropionated Direct esterification and alcoholysis of methyl or ethyl acrylate have been recommended for the preparation of the higher alkyl acrylates. ... [Pg.21]

The reaction of ethyl a-bromoacetate with 17-keto steroids such as estrone methyl ether or dehydroepiandrosterone acetate " under standard Reformatsky conditions is stereospecific, producing the 17 -ol in up to 80% yields. Ethyl a-bromopropionate reacts similarly but the yields are somewhat lower. [Pg.139]

A solution of 18 grams of ethyl 2-bromopropionate in 20 ml of tetrahydrofuran is then added to the cooled reaction mixture. After 24 hours at 20°C, the product is hydrolyzed by adding 200 ml of 5 weight percent methanolic sodium hydroxide followed by heating to reflux for 1 hour. The reaction mixture is then diluted with excess 1 N sulfuric acid and extracted with ether. The ether phase Is separated, evaporated to dryness and the residue is recrystallized from acetone-hexane to yield 2-(6-methoxv-2-naphthyl)propionic acid. [Pg.1060]

C 6H 7BrN402 97977-40-7) see Bamifylline benzyl 2-bromopropionate (CioH Br02 3017-53-6) see Mieropenem V-benzyl-tert-butylamine... [Pg.2304]


See other pages where Bromopropionate is mentioned: [Pg.427]    [Pg.427]    [Pg.430]    [Pg.431]    [Pg.432]    [Pg.978]    [Pg.376]    [Pg.28]    [Pg.296]    [Pg.297]    [Pg.39]    [Pg.141]    [Pg.141]    [Pg.57]    [Pg.120]    [Pg.635]    [Pg.635]    [Pg.1060]    [Pg.131]    [Pg.134]    [Pg.2295]    [Pg.2377]    [Pg.445]    [Pg.446]    [Pg.489]    [Pg.427]    [Pg.427]    [Pg.430]    [Pg.431]   
See also in sourсe #XX -- [ Pg.279 , Pg.445 ]




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2-bromopropionic acid ester

3- Pentyl a-bromopropionate

3-Bromopropionic acid

A-Bromopropionic acid

A-Bromopropionic acid, ethyl ester

A-bromopropionate

Ethyl /3-bromopropionate

Ethyl a-bromopropionate

Methyl -bromopropionate

Methyl-a-bromopropionate

O Bromopropionic Acid

O-Bromophenol 3-Bromopropionic acid, III

Preparation of a-Bromopropionic Acid

Reaction with /9-bromopropionic acid

Sec-Butyl a-bromopropionate

Sodium <>-bromopropionate

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