9- Bromocamphor sulphonation

The c -[Cr(en)2(OH2)F] + ion has been resolved with bromocamphor- -sulphonate ion, and anation with NCS and F ions in methanol is reported to proceed with retention of configuration. ... 

Of the reported analyses of bicyclo[2,2,l]heptane derivatives, that of the (—)-W-ethyl-N-methylalanine oxide (69) salt of (-(-)-3-bromocamphor-sulphonate (70) is of some crystallographic interest since the known... 

Cl9H2 3NO, p-Ethoxybenzylidene-p-n-butylaniline, 46B, 94 C19H28BrNOsS, (-)-N-Ethyl-N-methylaniline oxide (+)-3-bromocamphor-sulphonate, 38B, 143... 

ZZ-0-Cocaine. This was prepared by Willstatter and collaborators from synthetic (ZZ- -ecgonine. It crystallises in hexagonal plates, m.p. 81 5°, gives a hydrochloride, m.p. 208°, and differs from natural Z-cocaine in giving a sparingly soluble nitrate, ni.p. 172°. The hydrogen d-tartrate has m.p. 164°, -)- 39° and tlie d-a-bromocamphor- -sulphonate,... 

The resultant mixture can be separated by fractional crystallization as the trans-isomer is more soluble the m-isomer can be resolved into its enantiomers using optically active anions like a-bromocamphor 7r-sulphonate. These chlorides can be converted into the bromide or iodide complex by refluxing with a solution of the appropriate potassium halide. 

Ammonium d-a-bromocamphor-n-sulphonate [14575-84-9] M 328.2, m 284-285°(dec), [oc]q +84.8 (c 4, H2O). Passage of a hot aqueous soln through an alumina column removed water-soluble coloured impurities which remained on the column when the ammonium salt was eluted with hot water. The salt was crystd from water and dried over CaCl2 [Craddock and Jones JACS 84 1098 1962]. 

Homopiperonyl-phenyl-a-naphthylmethylarsonium bromide, [CeH2.CHj(02CH2)](C8Hs)(CioH,)(CH3)AsBr, crystallises from alcohol in colourless plates, M.pt. 174° to 175° C. It yields a d-a-bromocamphor-TT-sulphonate, crystallising in stout needles, which cannot be separated into two optically active forms. 

A report concerning the resolution of the benzophenarsazine 25 [where X =( + )- -bromocamphor-7c-sulphonate] was regarded by workers in the field to be too scant to be meaningful. Crystal structure determinations of the achiral compounds 26 and 27 revealed dihedral angles of 169.3° and 156.3° respectively, between the two halves the smaller angle in 27 indicated less aromaticity in this tricyclic ring system . ... 

Although ethylmethylphenylphosphine oxide was the first tetrahedral phosphorus compound to be resolved , only negative results were obtained when attempts were made to resolve methyl(a-naphthyl)phenylarsine oxide (142) by protonation and separation of (-i-)-a-bromocamphor-jc-sulphonate salts, or (c>-carboxyphenyl)methylphenyl-arsine oxide (143) or its anhydride 144 after protonation and use of (—)-brucine or (-l-)-morphine . The reversible combination of a tertiary arsine oxide with water was recognized at the outset and it is this property that is responsible for the racemization - ... 

Electron-impact mass spectral data have been recorded for the trifluoromethane-sulphonates (178 X = 0S02CF3, Y = H) and (178 X = H, Y = OSO2CF3). An Y-ray crystal structure determination of a minor product from the conversion of 3-bromocamphor into (-l-)-9-bromocamphor confirms the structure (179). The... 

The first criterion was to identify a crystalline diastereomeric salt of oxazinone ( )-l. Many chiral acids were screened and [(LS)-(endo,anti)]-(-)-3-bromocamphor-8-sulphonic acid (BCSA) afforded a 27% yield of the diastereomeric enriched (88% de) BCSA salt (Scheme 5). This was upgraded to 99% de with an 88% recovery after recrystallization from DMF//5o-propyl acetate (IPAC). A necessary physical property of... 

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