Bromobenzene Branch

Buchwald s reaction , which enables the preparation of [ C]arylamines from [ C]aryl 

In a procedure recommended for the preparation of iodo[U- C]benzene, a mixture of [U- C]benzene and 1.8 equivalents of iodine in 45% nitric acid was heated at 85 °C for 1.5 h. Vacuum distillation of the reaction product furnished a 4 1 mixture of iodo[U- C]-benzene and [U- C]benzene in almost quantitative radiochemical yield. Without separation into its components, the mixture was subjected to a copper catalyzed Ullman reaction at 288-290 °C to give [U- C]biphenyl in 65% overall radiochemical yield.  

Reaction conditions 1. Pd(OAc)2, xantphos, tart-BuONa, DMF 130°C (microwave, 120 W), 13 min 2. Pd2(dba)3,(S)-BINAP,fert-BuONa, toluene  

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