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Bromoacetophenones

This substance is conveniently obtained by treating p-bromoacetophenone (Section IV, 138) with the calculated quantity of bromine dissolved in glacial acetic acid ... [Pg.960]

Place a solution of 50 g. of p bromoacetophenone (Section IV,138) in 100 ml. of glacial acetic acid in a 500 ml. flask. Add very slowly (about 30 minutes) from a dropping funnel 40 g. (12-5 ml.) of bromine shake the mixture vigorously during the addition and keep the temperature below 20°. p-Bromophenacyl bromide commences to separate as needles after about half of the bromine has been introduced. When the addition is complete, cool the mixture in ice water, filter the crude product at the pump, and wash it with 50 per cent, alcohol imtil colourless (about 100 ml. are required). RecrystaUise from rectified (or methylated) spirit (ca. 400 ml.). The yield of pure p-bromophenac bromide (colourless needles, m.p. 109°) is 50 g. [Pg.961]

In 1892, Marchesini (94) described the synthesis of 4-phenyl-2-mercaptothiazole (62) by condensing bromoacetophenone with ammonium dithiocarbamate. [Pg.22]

Aralkyl or Alkylarylthiazoles and 2,4,5-Trisubstituted Thiazoles (Tables II-5 and II-6). Alkylthioamides and their substituted derivatives have been condensed with w-bromoacetophenones (28) to... [Pg.188]

N,N -Diacetylethylenediamine-N,N -dithioacetamide (42) reacts with oj-bromoacetophenone and its p-substituted derivatives to give the expected N,N -diacetyl-N,N -bis(4-phenyl-2-thiazolylmethylethylene diamine) (43) (Scheme 21) with R = H, Me, Cl, Br, MeO, yields ranged from 65 to 80% (482). [Pg.195]

Ary] 2-amino-5-(p-aminophenyl)thia2oles of the general formula 116 were prepared by condensing phenylthiosemicarbazides (115) with either w-bromoacetophenone by refluxing in alcohol for 2 hr (Method A) or with acetophenones and iodine on a steam bath for 8 hr (Method B) Scheme 53 (517), with R = para Me, MeO, Cl, Br, I, NOj, NHj, Ph ortho Me, NOjl or meta Br, I, NO. Yields ranged from 55 to 90% from Method A and 40 to 70% from Method B. [Pg.230]

Because the position of electrophilic attack on an aromatic nng is controlled by the direct ing effects of substituents already present the preparation of disubstituted aromatic com pounds requires that careful thought be given to the order of introduction of the two groups Compare the independent preparations of m bromoacetophenone and p bromoace tophenone from benzene Both syntheses require a Friedel-Crafts acylation step and a bromination step but the major product is determined by the order m which the two steps are carried out When the meta directing acetyl group is introduced first the final product IS m bromoacetophenone... [Pg.504]

Photolysis of 3-phenyl-2,l-benzisoxazole in 48% HBr produced reduction and substitution products via a proposed triplet state nitrenium ion intermediate (71HCA2111). Photolytic decomposition of 5-bromo-3-phenyl-2,l-benzisoxazole in 48% HBr gave 2-amino-5-bromoacetophenone and 2-amino-3,5-dibromoacetophenone (Scheme 18). A nitrenium ion intermediate was also proposed for the photolytic decomposition of 3-phenyl-2,l-benzisoxazole in concentrated HCl (Scheme 19) (7IHCA2111). [Pg.18]

Nuclear halogenation of acetophenone depends on formation of the aluminum chloride complex. If less than one equivalent of aluminum chloride is used, side-chain halogenation occurs. 3-Bromoacetophenone has been prepared from 3-aminoaceto-phenone by the Sandmeyer reaction. The synthesis described here has been taken from work of the submitters, who have used it to prepare many 3-bromo- and 3-chloroacetophenones and benzaldehydes, as well as more highly halogenated ones (Notes 7 and 8). [Pg.10]


See other pages where Bromoacetophenones is mentioned: [Pg.726]    [Pg.732]    [Pg.733]    [Pg.743]    [Pg.743]    [Pg.743]    [Pg.744]    [Pg.924]    [Pg.960]    [Pg.53]    [Pg.192]    [Pg.504]    [Pg.504]    [Pg.782]    [Pg.974]    [Pg.130]    [Pg.130]    [Pg.33]    [Pg.296]    [Pg.140]    [Pg.148]    [Pg.200]    [Pg.136]    [Pg.136]    [Pg.7]    [Pg.7]    [Pg.9]    [Pg.9]    [Pg.339]    [Pg.504]    [Pg.504]    [Pg.782]   
See also in sourсe #XX -- [ Pg.26 ]




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2-Bromoacetophenone, reaction

2-Bromoacetophenone, reaction with amines

3-Bromoacetophenone

3-Bromoacetophenone

4-Bromoacetophenone, oxidation

A-Bromoacetophenone

Acetophenone, 2-amino-, hydrochloride bromination to 3-bromoacetophenone

Acetophenone, bromination to 3-bromoacetophenone

Bromo Bromoacetophenone

Bromoacetic Bromoacetophenone

Cyclohexanone, 2-bromoreaction with bromoacetophenone

M-Bromoacetophenone

P-Bromoacetophenone

P-Bromoacetophenone bromination

P-Bromoacetophenone, molecular

P-Bromoacetophenone, molecular 13C NMR spectrum

P-Bromoacetophenone, molecular model

P-Bromoacetophenone, molecular symmetry plane

W-Bromoacetophenone

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