11 -Bromo-decanoic acid

A similar solid state method for the preparation of cyclic polymer has been reported. This method involves the synthesis of cyclic polymer obtained by a combination of inter-alkylation and intra-alkylation, i.e., cyclization of 11-bromo-decanoic acid. The cyclic polymer can be liberated from an anionic exchange resin. Thus, this method has the advantage that the cyclic product from the mixture after reaction is easily produced, as indicated in Fig. 50 [161]. 

Enarsoson, A., Spjuth, L., Liljenzin, J.O., Kallvenius, G., Hudson, M.J., Iveson, P.B., Russell, M.L., Madic, C., Cordier, P.Y. 1999. Separation of trivalent americium and europium with some substituted oligopyridines and triazines in synergy with 2-bromo-decanoic acid. In Solvent Extraction for the 21st Century, Proceedings of International Solvent Extraction Conference, ISEC 1999, Cox, M., Hidalgo, M., Valiente. M. Eds. Society of Chemical Industry (SCI) London, Vol. 1, 323-328. 

McCarthy and coworkers [34] used two methods to prepare (R)-2-bromo-decanoic acid (13), required as a synthon for inhibitors of acyl-coenzyme Axholesterol acyl transferase (Scheme 5.9). As an alternative to diazotiza-tion of commercially obtained (R)-2-aminodecanoic acid, racemic bromo acid was esterified directly under lipase catalysis to provide unreacted (13) in 76% ee the enantiomeric purity of the downstream thio acid (14) was improved by recrystallization of its dicyclohexylamine salt. 

Decanoic Acid 2-Bromo-hcptadeca-(Uioro-2H- ElObj. 37 (Cfl2 OH -> COOH)... 

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