Bromine “passenger

Macor also exploited the Mori-Ban indole synthesis to synthesize several anti-migraine analogues of sumatriptan and homo-tiyptamines as potent and selective serotonin reuptake inhibitors (SSRIs). Noticeably, the presence of the second bromine (the bromine passenger ) on the substrate was not significantly deleterious to the reaction although a small amount of the 7-bromoindole might be sacrificed at the end of the reaction to consume the active palladium catalyst. The approach to 7-bromoindole could provide a general method to access 7-bromoindoles (a rare class of indole derivatives), which then could be further manipulated for the synthesis of more complex 7-substituted indoles. 

Macor, J.E., Ogilvie, R.J. and Vythes, M.J. (1996) An improved s3mthesis of the unique anti-migraine agent CP-122,288 a bromine atom passenger in an intramolecular Heck reaction. 

By Water In the United States, in DOT approved cylinders on cargo vessels and on passenger vessels within Stowage category E limitations. Cylinders should also be stowed clear of living quarters, and separated from bromine, and chlorine. 

Hotzenblitz, a German company, has designed an electric vehicle to be powered specifically by a zinc/bromine battery (Fig. 39.10). The battery is 15 kWh 114 V and is located in a compartment under the passenger area, as shown in Fig. 39.11. It is sealed from the passenger area and is located between side impact barriers for safety. Specifications and performance data are given in Table 39.4. 

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