Bromine deficiency

Feed and foodstuffs in Europe contain bromine concentrations which exceed the normative requirement of animals and man. The normative requirement of goats was calculated to be > 1000 to 1500 pg kg feed DM. The bromine requirement of animals and man is met by feed, foodstuff and water (Anke etal. 2001) hence, bromine-deficiency experiments with rats, mice and chicks were generally unsuccessful (Winnek and Smith 1937, Huff etal. 1956, Bosshardt et al. 1956). 

As a result of the 7r-deficiency of the pteridine nucleus, alkyl pteridines are activated in the a-positions. The common reactions based on C—H acidity are found with a wide variety of compounds. Bromination of 6- and 7-methyl groups leads to mono- and di-substitution selective formation of the monobromomethyl derivatives has not yet been achieved satisfactorily. 6-Methylisoxanthopterin is claimed to give the 6-bromomethyl derivative with bromine in acetic and sulfuric acids at 100 °C for 2 min (50ZN(B)132) and with 1,7-dimethyl-lumazine a 90% yield of the 7-bromomethyl derivative (60CB2668) is obtained after 4h... 

The positive bromine which leads to bromonium ion intermediates is softer and also has unshared electron pairs which can permit a total of four electrons to participate in the bridged bromonium ion intermediate. This would be expected to lead to a more strongly bridged and more stable species than is possible in the case of the proton. The bromonium ion can be represented as having two covalent bonds to bromine and is electrophilic but not electron-deficient. 

When 7r-deficient thiadiazoles are fused to an azine, electrophilic substitution is possible only in the presence of strongly electron-donating substituents (74BCJ2813) (Scheme 56). Some [l,3,4]thiadiazolo[3,2-a]pyrimidin-5-ones were brominated next to the oxo group (90DOK743). 

The lack of steric effects in oxidations of hydrocarbons by Cr(VI) renders D and E unacceptable. The activated complex of scheme C is non-linear and hence does not comply with the magnitude of the observed isotope effect. Two pieces of evidence are quoted which indicate A to be the more probable of the remaining two. Firstly, the p constant of —1.17 is more in agreement with that obtained for bromine atom abstraction from toluenes (—1.369 to —1.806) than those found for solvolyses involving electron-deficient carbon ( — 2.57 to —4.67) . Secondly, the correlation between the relative rates of oxidation of the series... 

The Hofmann reaction of an amide with bromine and alkali apparently goes by way of the iV-bromoamide and unicovalent electron-deficient nitrogen. 

The formation of the bromoethoxycarbinol was unexpected, as there seems to be no previous record in the literature of the substitution of one halogen for another by a Grignard reagent. Even with a deficiency of the reagent, the only product which could again be isolated was the bromoethoxycarbinol. The replacement of an unreactive fluorine atom2 by the more reactive bromine is worthy of further investigation. 

Similarly, bromination of aromatic compounds as well as of electron-deficient olefins was carried out in good to excellent yields using (n-Bu4N)2S20g/Br2 or LiBr at 25 °C (equation 36)" . 

Electrophilic aromatic substitution of other benzo-fused v-deficient systems generally follows predictable pathways. Thus, benzopyrylium salts are in general resistant to electrophilic substitution even in the benzo-fused ring. Chromones behave somewhat similarly, although substitution can be effected under forcing conditions. Coumarins, on the other hand, undergo nitration readily in the 6-position while bromination results in substitution at the 3-position as a consequence of addition-elimination. 

The relative stabilities of radicals follow the same trend as for carhoca-tions. Like carbocations, radicals are electron deficient, and are stabilized by hyperconjugation. Therefore, the most substituted radical is most stable. For example, a 3° alkyl radical is more stable than a 2° alkyl radical, which in turn is more stable than a 1° alkyl radical. Allyl and benzyl radicals are more stable than alkyl radicals, because their unpaired electrons are delocalized. Electron delocalization increases the stability of a molecule. The more stable a radical, the faster it can be formed. Therefore, a hydrogen atom, bonded to either an allylic carbon or a benzylic carbon, is substituted more selectively in the halogenation reaction. The percentage substitution at allylic and benzyhc carbons is greater in the case of bromination than in the case of chlorination, because a bromine radical is more selective. 

Propagation The bromine radical is electron deficient and electrophilic. The radical adds to the double bond, generating a carbon-centred radical. This radical abstracts hydrogen from HBr, giving the product and another bromine radical. The orientation of this reaction is anfi-Markovnikov. The reversal of regiochemistry through the use of peroxides is called the peroxide effect. 

Methylene difluorocyclopropanes are relatively rare and their rearrangement chemistry has been reviewed recently [14]. In addition, electron deficient alkenes such as sesquiterpenoid methylene lactones may be competent substrates. Two crystal structures of compounds prepared in this way were reported recently [15,16]. Other relatively recent methods use dibromodifluoromethane, a relatively inexpensive and liquid precursor. Dolbier and co-workers described a simple zinc-mediated protocol [17], while Balcerzak and Jonczyk described a useful reproducible phase transfer catalysed procedure (Eq. 6) using bromo-form and dibromodifluoromethane [18]. The only problem here appears to be in separating cyclopropane products from alkene starting material (the authors recommend titration with bromine which is not particularly amenable for small scale use). Schlosser and co-workers have also described a mild ylide-based approach using dibromodifluoromethane [19] which reacts particularly well with highly nucleophilic alkenes such as enol ethers [20], and remarkably, with alkynes [21] to afford labile difluorocyclopropenes (Eq. 7). 

Electrophilic and nucleophilic reactions of 2-(2-thienyl)thieno[2,3-cf pyrimidine (346), prepared as shown in Scheme 99, permits a conclusion concerning the reactivity compared with that of thiophene bearing an electron deficient substituent in position 2. Both nitration and bromination primarily occur in the thiophene moiety whereas lithium organic reagents (methyllithium, butyllithium) add at carbon atom 4 (77BSF676). Bromination of (324) yields the 5- (or 6-) bromo derivative (68CR(C)(267)697). 

In our laboratory, Kokochashvili showed that the behavior of mixtures of hydrogen with bromine bears the same qualitative character in mixtures with deficient hydrogen the ratio of the limiting concentrations is quite large. In mixtures with excess hydrogen and deficient bromine the two limits practically coincide. 

Yates suggests that weak bridging between the bromine and the / carbon may occur in the intermediate even when the /3 carbon bears a benzene ring as shown in 22. But as the /3 carbon becomes less electron-deficient or as the solvating power of the solvent increases, this bridging becomes less important and the stereoselectivity decreases.34... 

This chapter represents an update to the previous two editions, published in 19771 and 19892, and covers the literature of the period 1989-1994 with some references to 1995 papers. It deals mainly with electrophilic additions across the C=C, C=Si and Si=Si bonds and includes both theoretical (ab initio calculations, orbital approach, molecular modelling etc.) and experimental aspects. Particular attention is paid to mechanistic studies, facial selectivity and neighbouring group participation. Synthetic utilization of electrophilic addition is discussed only if including substantial mechanistic insight purely synthetic work is not covered. Aside from the classical reactions, such as hydration, bromination etc., newly included material comprises aziridination (Section VI), attack at C=C bond by an electron-deficient carbon (Section VII) and those electrophilic reactions which utilize a transition or non-transition metal as the electrophile (Section VIII). 

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