Bromide with iodine metabolism

The exact mechanism(s) of bromide interference with iodine metabolism and with postnatal developmental processes in the young remains unresolved. 

Bromide Interference with Iodine Metabolism Goitrogenic and Whole-body Effects of Excessive Inorganic Bromide in the Rat... 

We provided evidence for a marked interference of excessive bromide intake in adult male rats with their whole-body metabolism of iodine (cf. Chapter 61, this volume). Here, we extend our overview on the effects of a high bromide intake in lactating rat dams on their own iodine metabolism, and on the well-being of the afflicted young. There are two main routes of iodine elimination from the... 

We therefore suggest that high levels of bromide in the body of experimental animals could influence their iodine metabolism in two parallel ways by a decrease in iodide accumulation in the thyroid and by a rise in iodide excretion by the kidneys. A high surplus of bromide ions in the blood, which was, under our experimental conditions, several thousand times greater than the concentration of iodide, could competitively inhibit the access of iodide into the thyroid and could replace a part of the iodide in the gland with bromide. By accelerating the renal excretion of iodide, excessive bromide could also influence the pool of exchangeable iodide in the thyroid (Pavelka et al.,... 

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