Bromide Nasal Spray

Atrovent (ipratropium bromide) Nasal Spray 0.03% is a metered-dose, manual-pump spray unit that delivers 21 meg (70, uL ) ipratropium bromide per spray on an anhydrous basis in an isotonic, aqueous solution with pH 

25 g of micronized salbutamol are weighed into a pressure-addition vessel. 

After sealing and evacuation thereof, 10.5 kg of HFA 227 that has previously been aerated 

After homogenization of this mixture, the suspension obtained is dispensed into aluminum containers sealed with metering valves by means of the pressure-filling technique. 

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Special risk Ipratropium bromide nasal spray should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, or bladder neck obstruction. 

Dockhorn R, Aaronson D, Bronsky E, Chervinsky P, Cohen R, Ehtessabian R, Finn A, Grossman J, Howland W, Kaiser H, Pearhnan D, Sublet J, Ratner P, Settipane G, Sim T, Storms W, Webb R, Drda K, Wood C. Ipratropium bromide nasal spray 0.03% and beclometha-sone nasal spray alone and in combination for the treatment of rhinorrhea in perennial rhinitis. Ann Allergy Asthma Immunol 1999 82(4) 349-59. 

Bronsky EA, Druce H, Findlay SR, Hampel FC, Kaiser H, Ratner P, Valentine MD, Wood CC. A chnical trial of ipratropium bromide nasal spray in patients with perennial nonallergic rhinitis. J Allergy Chn Immunol 1995 95(5 Pt 2) 1117-22. 

Ipratropium bromide (Atrovent) nasal spray is an anticholinergic agent useful in perennial allergic rhinitis. 

For symptomatic relief of rhinorrhea associated with seasonal allergic rhinitis-The recommended dose of ipratropium bromide 0.06% nasal spray is 2 sprays (84 meg) per nostril 4 times daily (total dose 672 meg/day) in adults and children 5 years of age and older. 

The safety and efficacy of the use of ipratropium bromide 0.06% nasal spray beyond 3 weeks in patients with seasonal allergic rhinitis have not been established. 

Intranasal anticholinergic agents (e.g., ipratropium) reduce the severity and duration of rhinorrhea but have no effect on other nasal symptoms.11,12,21 Ipratropium reduces cholinergic hyperreactivity and cholinergically mediated histamine- and antigen-induced secretion. Intranasal ipratropium acts locally, with only minimal systemic absorption. Clinical trials demonstrated that ipratropium bromide 0.3% reduced rhinorrhea in adults and children with PAR.11,12 Intranasal ipratropium is an option for patients in whom rhinorrhea is refractory to topical intranasal corticosteroids and/or antihistamines.8,12 Intranasal ipratropium is available only by prescription, and the dose is two sprays nasally two to three times daily.15 Adverse effects are minimal, but dry nasal membranes have been reported.11,12... 

Nasal corticosteroids are effective in vasomotor rhinitis, but because of the duration of the disorder, certain caution is advised to avoid systemic effects and local adverse reactions after long-term use. Ipratropium bromide spray works well if the dominating problem is runny nose. 

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