Brody distribution

Brody distribution, permutational symmetry, dynamic Jahn-Teller and geometric phase effects, 708-711... 

An interpolating function between the Poisson and the Wigner distribution is given by the Brody distribution (Brody, 1973) reading for the... 

K4. Keen, P., Effect of binding to plasma proteins on the distribution, activity and elimination of drugs. In Concepts in Biochemical Pharmacology (B. B. Brodie and J. R. Gillette, eds.). Handbook of Experimental Pharmacology, Vol. 28, Part 1, pp. 213-233. Springer-Verlag, Berlin and New York, 1971. 

C.A. Glomski, H. Brody, and S.K.K. Pillay, Distribution and concentration of mercury in autopsy specimens of human brain. Nature (London) 232 200, 1971. 

As noted above, only a tiny fraction of inhaled fibers penetrate through the epithelial layer of the lungs. No quantitative studies were located regarding the distribution of these fibers in the rest of the body after inhalation exposure, but some appear to be retained in the pleura, with others passing into the lymphatics (Brody 1993 Hillerdal 1980 Holt 1983 Rudd 1989). Those fibers that enter the lymphatics are... 

Reproduced from B. B. Brodie, in Absorption and Distribution of Drugs (ed. T. Binns), Livingstone, Edinburgh, 1964. 

The distribution of enzyme activity was analyzed in subcellular fractions nucleic, mitochondrial, microsomal, and cytosol (Eiseman et al. 1972). The maximum activity was found in the cytosol, which is the site of other nitroreductases, although nitroreductases can also be located in microsomes (Fouts and Brodie 1957 Juchau et al. 1970 Kamm and Gillette 1963 Kato et al. 1969 Parker 1952). The properties of nitroreductases have been extensively studied for the reduction of p -nitrobenzoic acid (Kato et al. 1969). Two separate enzyme systems are involved, one located in the cytosol, and the other in the microsomes. Both forms require the presence of reduced nicotinamide adenine dinucleotides (NADH or NADPH) (Kato et al. 1969). The cytosolic reducing activity for... 

Figure 7.9 A. Illustrates the differences in perfusion rate on the proposed distribution and redistribution of thiopental. (Redrawn from http //www.cvm.okstate.edu/Courses/vmed5412/LECT006.htm) B. Drug equilibration in the cerebrospinal fluid with plasma water for various drugs in the dog (redrawn from Figure 5-11 in Rowland and Tozer, 2006, and Brodie et al., 1960. Plasma drug concentration was kept constant throughout the study. Thiopental displays perfusion limited distribution whereas the distribution of salicylic acid is permeability rate limited.

W G Anton AH, A drug-induced change in the distribution and renal excretion of sulfonamides, JPET, 134, 291-303 (1961). NB The value was obtained from Dayton PG, personal communication. Originally measured by Burns JJ, Wexler S and Brodie BB, The isolation and characterization of a metabolic product of 3,3 -carboxy-methylene-bis-(4-hydroxycoumarin) ethyl ester (Tromexan) from human urine, JACS, 75,2345-2346 (1953). 

Brodie, M.L. and Cohen, R.J., Measurements of cluster-size distributions arising in salt-induced aggregation of polystyrene microspheres, J. Colloid Interface Sci., 153, 493, 1992. 

The density of the 7=3 states determined from the experimental data (Krasznahorkay et al. 1999) is close to a Wigner quasi-probability distribution (Brody et al. 1981) but the mixing-in of some Poisson type distribution is also visible. The density of / = 3 states has also been calculated using the back-shifted Fermi-gas description with parameters determined by Rauscher et al. (1997). The calculated curve had to be shifted by 2.7 MeV to reproduce the experimental values (Krasznahorkay et al. 1999). The energy of the ground state in the third well is obtained to be Em = (3.1 0.4) MeV. 

Wallace GB, Brodie BB. The distribution of administered iodide and thiocyanate in comparison with chloride, and their relation to body fluids. JPharmacol Exp Ther 6U391-411, 1937. 

Brody AR, Roe MW, Evans JN, et al. Deposition and translocation of inhaled silica in rats quantification of particle distribution, macrophage participation, and particle distrihution in alveolar ducts. Lah Invest 1982 47(6) 533-542. 

Perdue TD, Brody AR. Distribution of transforming growth factor-beta 1, fibro-nectin, and smooth muscle actin in asbestos-induced pulmonary fibrosis in rats. J Histochem Cytochem 1994 42(8) 1061-1070. 

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