Brevibacterium heali

Methionine is overproduced by auxotrophic and analogue-resistant mutants. E. coli K-12 mutant resistant to methionine analogues (norleucine, ethionine, and methyl methionine) produced 2mg/ml of methionine. A multianalogue-resistant mutant of Corynebacterium lilium resistant to ethionine, norleucine, and methionine sulfoxide yielded 2.3 g/L methionine in a 5L fermenter.Methionine production from different analogue-resistant yeasts are also reported in the late 1970s and 1980s. ° Mondal et al. have reported methionine production from methionine-analogue-resistant mutants of Brevibacterium heali. 

Mondal S, Chatterjee SP. Enhancement of methionine production by methionine analogue resistant mutants of Brevibacterium heali. Acta Biotechnol 1994 14 199-204. 

---

See also in sourсe #XX -- [ ]

---