Normal breast tissue comparisons

Comparisons of MRS data for normal, fibroadenoma, and malignant breast tissues... 

Rizk, S.L. and Sky-Peck, H.H. (1984). Comparison between concentrations of trace elements in normal and neoplastic human breast tissue. Cancer Res. 44, 5390-5394. 

Laser capture microdissection was combined with MALDl-MS by several groups [49-52], In one study, the MALDl analysis of microdissected cells from human breast cancer in comparison to normal breast epithelial cells was reported [49], with more than 40 peaks in the MALDl mass spectra being found to differ in intensity between the cancer and normal tissues. This approach represents another way of achieving laterally resolved analytical information. In this case, it was not the focus size of the desorbing laser beam in the mass spectrometer. 

Some early studies demonstrated the potential of the new technology [39-41] to examine the differences between normal and malignant colonic tissue [39] and identifying potential subclassifications of breast cancer [41]. An interesting aside to these studies was the different analytical methods used by the authors to analyze and interpret the data. This variability of approach remains a feature of microarray studies and can hinder the comparison of data from different studies. However, there are now processes in place which attempt to standardize at least some of the analyses [42],... 

---