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Breast pure antiestrogen therapy

Menopause is thus the condition in most urgent need of tissue- or cell-targeted endocrine therapy. In fact, estrogen-like compounds are required for prevention of bone loss and cardiovascular disease. On the other hand, for the breast and endometrium, the ideal approach is a pure antiestrogen that would inhibit the development and growth of breast and endometrial carcinoma. The effects required in the skeletal and cardiovascular systems (estrogenic) are thus the opposite of those required in the breast and endometrium, for which antiestrogenic activity is recommended. [Pg.299]

Stimulated by the need for an improved therapy for breast cancer, considerable efforts have been devoted to the synthesis of compounds that would exert pure antiestrogenic activity in the mammary gland and uterus. As mentioned above, while tamoxifen has beneficial effects on breast cancer, it clearly acts as an estrogen agonist in the endometrium, leading to an increased rate of endometrial carcinoma in women taking tamoxifen under chronic conditions. Moreover, it is most likely that a pure antiestrogen will have beneficial effects superior to those of tamoxifen in breast cancer prevention and treatment. [Pg.318]


See other pages where Breast pure antiestrogen therapy is mentioned: [Pg.169]    [Pg.1115]    [Pg.75]    [Pg.153]    [Pg.154]    [Pg.302]    [Pg.328]    [Pg.331]    [Pg.344]    [Pg.353]    [Pg.1115]    [Pg.167]    [Pg.170]    [Pg.242]   
See also in sourсe #XX -- [ Pg.169 ]




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