Breast cancer progesterone receptor status

Biesterfeld, S., Veuskens, U., Schmitz, F.-J., Amo-Takyi, B., and Bocking, A. 1996. Interobserver reproducibility of immunocytochemical estrogen and progesterone receptor status assesment in breast cancer. Anticancer Res. 76 2497-2500. 

Bardou, V.-J., Arpino, G., Elledge, R.M., Osborne, C.K., and Clark, G.M. 2003. Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases. J. Clin. Oncol. 21, 1973-1979. 

The p53 protein can also been measured by other methods. The LIA method is intended for measurement of the p53 protein in tumor cytosols normally prepared for the routine biochemical measurement of the oestrogen and progesteron receptor status. The LIA method has been demonstrated to be useful and to give prognostic information in a breast cancer material (34). The principal laboratory steps are outlined in Table 3. The LIA measurement of the p53 protein has been compared with immunohistochemical expression and cDNA-based sequencing on more than 200 primary breast cancers (Norberg et al., unpublished data). In brief, the LIA technique seems to have the same principal limitations as the immunohistochemical determination, and the sensitivity and specificity is no better than with immunohistochemical determination. 

The relation between estrogen and progesterone receptor status, menstrual status, relapse-free survival, and overall survival was analyzed in 411 patients with early breast cancer randomized to receive either postoperative adjuvant chemo-... 

B3. Beex, L. V., Mackenzie, M. A., Raemaekers, J. M., Smals, A. C., Benraad, T. J., and Klop-penboig, P. W., Adjuvant chemotherapy in premenopausal patients with primary breast cancer, relation to drug-induced amenorrhoea, age and the progesterone receptor status of the tumour. Eur. J. Cancer Clin. Oncol. 24(4), 719-721 (1988). 

Bll. Boijesson, B. W., and Tesoriero, C. J., Effects of molybdate on classification of estrogen and progesterone receptor status in human breast cancer. J. Steroid Biochem. 23(6A), 949-953... 

Melchor, J. C., Rodriguez-Escudero, F. J., Lujan, S., and Corcostegui, B., Variation of estrogen and progesterone receptor status in breast cancer after tamoxifen therapy. Oncology 47(6), 467-470 (1990),... 

Based on these observations, a series of studies have evaluated the relationship between the estrogen and/or progesterone receptor-status and the retinoid activities. The first observations indicated the ability of the retinoic acid to influence the levels of progesterone receptor (PgR) [15], in terms of a decrease in PgR mRNA and protein in ER" breast cancer cell lines, probably through an inhibition of PR gene transcription, concomitant of an impaired progestin responsiveness [16]. 

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