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Breast cancer associated protein 1 Brcal

With chromatin-remodeling complexes Involved in so many cases of transcriptional control. It Is expected that Swi/Snf and similar complexes will be linked to many cancers. In humans, for example, mutations In Brgl, which encodes the Swi/Snf catalytic subunit, have been found in prostate, lung, and breast tumors. Components of the Swi/Snf complex also have been found to associate with BRCAl, a nuclear protein that helps suppress human breast cancer. BRCA-1 Is Involved In the repair of double-strand DNA breaks (discussed In the final section of this chapter) and In transcriptional control, so the Swi/Snf complex may assist BRCA-1 In these functions. [Pg.958]


See other pages where Breast cancer associated protein 1 Brcal is mentioned: [Pg.295]    [Pg.47]    [Pg.407]    [Pg.105]    [Pg.2727]    [Pg.222]    [Pg.215]    [Pg.392]    [Pg.238]    [Pg.23]    [Pg.357]    [Pg.104]    [Pg.970]    [Pg.53]    [Pg.252]    [Pg.187]    [Pg.53]   
See also in sourсe #XX -- [ Pg.49 , Pg.50 , Pg.53 ]




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