Brain relaxation parameters

Van Dorsten FA, Olah L, Schwindt W, Grune M, Uhlenkuken U, Pillekamp F, Hossmann KA, Hoehn M (2002) Dynamic changes of ADC, perfusion, and NMR relaxation parameters in transient focal ischemia of rat brain. Magn Reson Med 47 97-104... 

For all these techniques, the general qualitative correlation between the measured parameter and the iron concentration was established. However, the measurements are too sensitive to the parameters of the experimental procedures and to physiological data beyond the iron content to allow for routine use in hospitals (43). Indeed, the relaxivity of ferritin is different in solutions, in the liver, in the spleen, in the brain, etc., which implies that MRI quantification protocols must be developed separately for each organ. 

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